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KMID : 0356920100580040374
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Korean Journal of Anesthesiology
2010 Volume.58 No. 4 p.374 ~ p.377
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Effects of propofol on β-adrenoceptor-mediated signal transduction in cardiac muscle; role of cAMP
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Chang Chul-Ho
Roh Go-Un
Park Wyun-Kon
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Abstract
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Background: Propofol may decrease myocardial contractility via actions on the β-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via β-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate).
Methods: The effects of propofol on β-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPγS, and forskolin) of each step of β-adrenoceptor-mediated cascades.
Results: While the production of cAMP stimulated by isoproterenol, GTPγS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 μM) did not alter the levels of cAMP.
Conclusions: Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPγS, and forskolin, propofol appears to have no effect on the β-adrenoceptor signaling pathway in guinea pig ventricular myocardium.
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KEYWORD
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β-adrenoceptor, cAMP, G-protein, Propofol
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